Transaminase Inhibition by 2 Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma: Cell Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis: Cell Reports You most likely have chronic inflammation if you suffer from any chronic health symptoms, particularly pain, fatigue, or brain fog. Common signs and symptoms of chronic inflammation: 1. Gut health problems 2. Prolyl hydroxylase inhibition protects the kidneys from ischemia via upregulation of glycogen storage Kidney International